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Scientific Publications

Preprint on Phenotypic Reliability

July 23, 2022

Biomarkers of behavior and psychiatric illness for cognitive and clinical neuroscience remain out of reach14. Suboptimal reliability of biological measurements, such as functional magnetic resonance imaging (fMRI), is increasingly cited as a primary culprit for discouragingly large sample size requirements and poor reproducibility of brain-based biomarker discovery1,57. In response, steps are being taken towards optimizing MRI reliability and increasing sample sizes811, though this will not be enough. Optimizing biological measurement reliability and increasing sample sizes are necessary but insufficient steps for biomarker discovery; this focus has overlooked the ‘other side of the equation’ – the reliability of clinical and cognitive assessments – which are often suboptimal or unassessed.

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Tagged with: Science and Research