Ritalin: What You Don’t Know About Its Metabolism and Inter-Individual Variability
John S. Markowitz, PharmD, University of Florida College of Pharmacy
Methylphenidate is the most commonly prescribed psychostimulant for ADHD in the world. Although it has been in continuous clinical use since the 1950s, there remains some unpredictability in patient response and optimal dosing strategies. Factors contributing to these uncertainties will be discussed in the lecture.
– Describe the pertinent parameters of methylphenidate metabolism and the interindividual variability associated with long-acting formulations.
– Understand how methylphenidate and structurally related compounds can interact uniquely with alcohol.
– Describe the role of the hepatic enzyme carboxylesterase 1 (CES1) in the metabolism of methylphenidate, and how genetic variants of the CES1 gene can influence the concentrations of methylphenidate in carriers vs non-carriers.
About the Visiting Professor Lecture Series:
The Child Mind Institute Visiting Professor Lecture Series invites leaders in the field of child and adolescent mental health to talk about the latest research and treatment protocols. All events are open to the public. This year, all lectures will be hosted virtually over GoToWebinar. Continuing medical education (CME) credits for psychiatrists and continuing education (CE) credits for psychologists are through our partnership with Northwell Health.